Dataset Information

Prognostic Value of Intratumor Metabolic Heterogeneity Parameters on ¹⁸F-FDG PET/CT for Patients with Colorectal Cancer.

ABSTRACT:

Purpose

Intratumor metabolic heterogeneity parameters on ¹⁸F-2-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) positron emission tomography-computed tomography (PET-CT) have been proven to be predictors of the clinical prognosis of cancer patients. The study aimed to examine the correlation between ¹⁸F-FDG PET-CT-defined heterogeneity parameters and the prognostic significance in patients with colorectal cancer.

Methods

The study included 188 patients with colorectal cancer who received surgery and ¹⁸F-FDG PET/CT examinations. Preoperative ¹⁸F-FDG PET/CT conventional and metabolic heterogeneity parameters were collected, including maximum, peak, and mean standardized uptake value (SUVmax, SUVpeak, and SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG), heterogeneity index-1 (HI-1) and heterogeneity index-2 (HI-2), and clinicopathological information. Correlations between these parameters and patient survival outcomes were inferred.

Results

The associations between ¹⁸F-FDG PET/CT parameters and clinical outcomes were analyzed. Tumor thrombus (P < 0.001), tumor stage (P=0.001), MTV (P=0.003), HI-1 (P=0.032), and HI-2 (P=0.001) differed between the two groups with and without recurrence. Multivariate analysis showed that, in the radical surgery group, HI-2 (HR = 1.10, 95% CI: 1.04-1.17, P=0.001), tumor stage (HR = 20.65, 95% CI: 4.81-88.62, P < 0.001), and regional lymph nodes status (HR = 0.16, 95% CI: 0.04-0.57, P=0.005) were independent variables significantly correlated with progression-free survival (PFS) and HI-2 (HR = 1.16, 95% CI: 1.07-1.26, P < 0.001) was an independent variable affecting overall survival (OS). In the palliative surgery group, HI-2 (HR = 1.03, 95% CI: 1.01-1.06, P=0.020) was an independent variable affecting PFS, and all the parameters were not statistically significant for OS.

Conclusion

HI-2, tumor stage, and regional lymph nodes status might predict the outcomes of colorectal cancer more effectively than other ¹⁸F-FDG PET/CT defined parameters.

SUBMITTER: Liu X

PROVIDER: S-EPMC8818395 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Prognostic Value of Intratumor Metabolic Heterogeneity Parameters on <sup>18</sup>F-FDG PET/CT for Patients with Colorectal Cancer.

Liu Xin X Xiang Kun K Geng Guang-Yong GY Wang Shi-Cun SC Ni Ming M Zhang Yi-Fan YF Pan Hai-Feng HF Lv Wei-Fu WF

Contrast media & molecular imaging 20220130

<h4>Purpose</h4>Intratumor metabolic heterogeneity parameters on <sup>18</sup>F-2-fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) positron emission tomography-computed tomography (PET-CT) have been proven to be predictors of the clinical prognosis of cancer patients. The study aimed to examine the correlation between <sup>18</sup>F-FDG PET-CT-defined heterogeneity parameters and the prognostic significance in patients with colorectal cancer.<h4>Methods</h4>The study included 188 patients with colo ...[more]

PMID: 35173559

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Dataset Information

Prognostic Value of Intratumor Metabolic Heterogeneity Parameters on ¹⁸F-FDG PET/CT for Patients with Colorectal Cancer.

Purpose

Methods

Results

Conclusion

Publications

Prognostic Value of Intratumor Metabolic Heterogeneity Parameters on <sup>18</sup>F-FDG PET/CT for Patients with Colorectal Cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Prognostic Value of Intratumor Metabolic Heterogeneity Parameters on 18F-FDG PET/CT for Patients with Colorectal Cancer.

Purpose

Methods

Results

Conclusion

Publications

Prognostic Value of Intratumor Metabolic Heterogeneity Parameters on <sup>18</sup>F-FDG PET/CT for Patients with Colorectal Cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Prognostic Value of Intratumor Metabolic Heterogeneity Parameters on ¹⁸F-FDG PET/CT for Patients with Colorectal Cancer.