Impact of sex and APOE ε4 on the association of cognition and hippocampal volume in clinically normal, amyloid positive adults.

ABSTRACT:

Introduction

Cognitive decline follows pathological changes including neurodegeneration on the Alzheimer's disease continuum. However, it is unclear which cognitive domains first become affected by neurodegeneration in amyloid-positive individuals and if sex or apolipoprotein (APOE) ε4 status differences affect this relationship.

Methods

Data from 1233 cognitively unimpaired, amyloid-positive individuals 65 to 85 years of age were studied to assess the effect of hippocampal volume (HV) on cognition and to evaluate differences due to sex and APOE ε4 status.

Results

Lower HV was linked with worse performance on measures of memory (free recall, total recall, logical memory delayed recall, Mini-Mental State Examination [MMSE]), executive functioning (digit s

SUBMITTER: Petersen KK 

PROVIDER: S-EPMC8828988 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature