Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition.

ABSTRACT:

Introduction

It is important to understand which biological processes change with aging, and how such changes are associated with increased Alzheimer's disease (AD) risk. We studied how cerebrospinal fluid (CSF) proteomics changed with age and tested if associations depended on amyloid status, sex, and apolipoprotein E Ɛ4 genotype.

Methods

We included 277 cognitively intact individuals aged 46 to 89 years from Alzheimer's Disease Neuroimaging Initiative, European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery, and Metabolic Syndrome in Men. In total, 1149 proteins were measured with liquid chromatography mass spectrometry with multiple reaction monitoring/Rules-Based Medicine, tandem mass tag mass spectrometry, and SOMAscan. We tested as

SUBMITTER: Wesenhagen KEJ 

PROVIDER: S-EPMC9074716 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature