Reduced ADAMTS13 Activity in Correlation with Pathophysiology, Severity, and Outcome of COVID-19: A Retrospective Observational Study.

ABSTRACT:

Background

Low ADAMTS13 activity has been suggested to be an interplaying factor in the pathogenesis of COVID-19, considering that it is a thromboinflammatory disease with high risk of microthrombosis.

Objectives

The study aimed to explore the correlation between ADAMTS13 activity and the pathophysiological pathway of COVID-19.

Methods

We carried out a retrospective observational study of 87 patients with COVID-19 in NMC Royal Hospital, Abu Dhabi, UAE. ADAMTS13 activity was measured and compared with patients' characteristics and clinical outcomes.

Results

Low ADAMTS13 activity was associated with pneumonia (p = 0.007), severity of COVID-19 (p <0.001), and mechanical ventilation rates (p = 0.018). Death was more frequently observed among patients (5 patients) w

SUBMITTER: Hafez W 

PROVIDER: S-EPMC8839807 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature