Cell cycle arrest biomarkers for predicting renal recovery from acute kidney injury: a prospective validation study.

ABSTRACT:

Background

Acute kidney injury (AKI) is a common disease in the intensive care unit (ICU). AKI patients with nonrecovery of renal function have a markedly increased risk of death compared with patients with recovery. The current study aimed to explore and validate the utility of urinary cell cycle arrest biomarkers for predicting nonrecovery in patients who developed AKI after ICU admission.

Methods

We prospectively and consecutively enrolled 379 critically ill patients who developed AKI after admission to the ICU, which were divided into a derivation cohort (194 AKI patients) and a validation cohort (185 AKI patients). The biomarkers of urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) were detected at inclusi

SUBMITTER: Jia HM 

PROVIDER: S-EPMC8840946 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature