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Concurrent and Longitudinal Associations of Sex and Race with Inflammatory Biomarkers during Adolescence.


ABSTRACT: Chronic, systemic inflammation is implicated in physical and mental health; little is known about whether sex and racial differences detected in adulthood are observed during adolescence or about normative changes occurring during adolescence. This longitudinal, United States-based study examined four biomarkers of systemic inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-8) in 315 adolescents (51% female; 58% black; baseline age = 16.49 years (SD = 1.56; range: 12.14-21.28)] at three timepoints. Notable results included: general decline in inflammatory biomarkers in older adolescents, lower levels of TNF-α/IL-8 in black adolescents, elevated CRP/IL-6 in females, and especially higher levels of IL-6 in black, female adolescents. Implications are discussed, particularly the potential health implications of elevated IL-6 in black females.

SUBMITTER: Mac Giollabhui N 

PROVIDER: S-EPMC8845075 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Concurrent and Longitudinal Associations of Sex and Race with Inflammatory Biomarkers during Adolescence.

Mac Giollabhui Naoise N   Alloy Lauren B LB   Swistun Dominika D   Coe Christopher L CL   Ellman Lauren M LM   Moriarity Daniel P DP   Stumper Allison C AC   Abramson Lyn Y LY  

Journal of youth and adolescence 20210115 4


Chronic, systemic inflammation is implicated in physical and mental health; little is known about whether sex and racial differences detected in adulthood are observed during adolescence or about normative changes occurring during adolescence. This longitudinal, United States-based study examined four biomarkers of systemic inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-8) in 315 adolescents (51% female; 58% black; baseline age = 16.49 y  ...[more]

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