A comprehensive neuromonitoring approach in a large animal model of cardiac arrest.

ABSTRACT:

Background

Anoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post-resuscitation phase, but a detailed model that includes extensive neuromonitoring is lacking.

Method

Before an electrically-induced 10-minute CA and resuscitation, 46 adult pigs underwent neurosurgery for placement of a multifunctional probe (intracranial pressure or ICP, tissue oxygen tension or PbtO₂ and cerebral temperature) and a bolt-based technique for the placement and securing of a regional blood flow probe and two sEEG electrodes; two modified cerebral microdialysis (CMD) probes were also inserted in the frontal lobes and accidental misplacement was prevented using a perforated head support.

Result

42 animals underwent the CA procedure and 41 achieved the return of spontaneous circulation (ROSC). In 4 cases (8.6%) an adverse event took place during preparation, but only in two cases (4.3%) this was related to the neurosurgery. In 6 animals (13.3%) the minor complications that occurred resolved after probe repositioning.

Conclusion

Herein we provide a detailed comprehensive neuromonitoring approach in a large animal model of CA that might help future research.

SUBMITTER: Annoni F 

PROVIDER: S-EPMC8879632 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature