Optimising tumour coverage and organ at risk sparing for hypofractionated re-irradiation in glioblastoma.

ABSTRACT:

Background and purpose

Re-irradiation may be used for recurrent glioblastoma (GBM) patients. In some cases Planning Target Volume (PTV) under-coverage is necessary to meet organ at risk (OAR) constraints. This study aimed to develop a Volumetric Modulated Arc Therapy planning solution for GBM re-irradiation including a means of assessing if target coverage would be achievable and how much PTV 'cropping' would be required to meet OAR constraints, based on PTV volume and OAR proximity.

Materials and methods

For 10 PTVs, 360°, 180°, two coplanar 180° and 180° + non-coplanar 45° arc arrangements were compared using 35 Gy in 10 fractions. Using the preferred arrangement, dose fall-off was modelled to determine the separation required between PTV and OAR to ensure OAR dose constra

SUBMITTER: Pagett CJH 

PROVIDER: S-EPMC8881705 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature