Variations in clot phenotype following injury: The MA-R ratio and fragile clots.

ABSTRACT:

Introduction

Trauma-induced coagulopathy is a continuum ranging from hypercoagulable to hypercoagulable phenotypes. In single-center studies, the maximum amplitude (MA) to r-time (R) (MA-R) ratio has identified a phenotype of injured patients with high mortality risk. The purpose of this study was to determine the relationship between MA-R and mortality using multicenter data and to investigate fibrinogen consumption in the development of this specific coagulopathy phenotype.

Methods

Using the Pragmatic Randomized Optimal Platelet and Plasma Ratios data set, patients were divided into blunt and penetrating injury cohorts. MA was divided by R time from admission thromboelastogram to calculate MA-R. MA-R was used to assess odds of early and late mortality using multivariable m

SUBMITTER: Harrington J 

PROVIDER: S-EPMC8887779 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature