Diet and Risk of Myeloproliferative Neoplasms in Older Individuals from the NIH-AARP Cohort.

ABSTRACT:

Background

The etiology of myeloproliferative neoplasms (MPN) is obscure, and no previous studies have evaluated the role of diet.

Methods

In the NIH-AARP Diet and Health Study, a prospective cohort of 463,049 participants ages 50 to 71 years at baseline (1995-1996), we identified 490 MPN cases after a median follow-up of 15.5 years, including 190 with polycythemia vera (PV) and 146 with essential thrombocythemia (ET). We examined possible associations between various dietary factors and the risk of MPN as a group, as well as PV and ET, using multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) and adjust for potential confounding variables.

Results

An increased risk was observed between fruit consumption and t

SUBMITTER: Podoltsev NA 

PROVIDER: S-EPMC8895351 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature