APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age.

ABSTRACT:

Background

The E4 allele of the APOE gene is known to be associated with cognitive impairment. However, a limited number of studies have examined the association between the E2 allele and longitudinal changes of cognitive function.

Objective

To determine whether rates of cognitive change differ in carriers of the APOE E2 allele compared to other genotypes.

Methods

We conducted a secondary analysis of data from two ongoing longitudinal cohort studies, the Long Life Family Study (LLFS) and New England Centenarian Study (NECS). We included participants who had APOE genotyping data, data from longitudinal administrations of the Telephone Interview for Cognitive Status (TICS), and age, sex, and education available. We assessed whether cognitive change as measured by rate o

SUBMITTER: Sweigart B 

PROVIDER: S-EPMC8896199 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature