AKR1B10 as a Potential Novel Serum Biomarker for Breast Cancer: A Pilot Study.

ABSTRACT:

Background

Aldo-keto reductase 1B10 (AKR1B10) is a secretory protein that is upregulated in breast cancer.

Objective

This case-controlled pilot study evaluated the serum level of AKR1B10 in healthy women and patients with a localized or metastatic breast cancer.

Methods

AKR1B10 levels were measured by ELISA and IHC in several patient cohorts.

Results

Our data showed that serum AKR1B10 was significantly elevated in patients with localized (6.72 ± 0.92 ng/ml) or metastatic (7.79 ± 1.13 ng/ml) disease compared to cancer-free healthy women (1.69 ± 0.17 ng/ml) (p<0.001); the serum AKR1B10 was correlated with its expression in tumor tissues, but not with the tumor burden, molecular subtypes or histological stages. After surgical removal of primary tumors, the serum A

SUBMITTER: Cao Z 

PROVIDER: S-EPMC8908957 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature