Association between plasma proteome and childhood neurodevelopmental disorders: A two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Childhood neurodevelopmental disorders, including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS), comprise a major cause of health-related disabilities in children. However, biomarkers towards pathogenesis or novel drug targets are still limited. Our study aims to provide a comprehensive investigation of the causal effects of the plasma proteome on ASD, ADHD, and TS using the two-sample Mendelian Randomization (MR) approach.

Methods

Genetic associations with 2994 plasma proteins were selected as exposures and genome-wide association data of ASD, ADHD, TS were utilized as outcomes. MR analyses were carried out using the inverse-variance weighted method, and the MR-Egger and weighted median methods were us

SUBMITTER: Yang J 

PROVIDER: S-EPMC8933670 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature