Causal association between body mass index and temporomandibular disorders: a bidirectional two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Observational studies have shown that body mass index (BMI) is highly correlated with the occurrence of temporomandibular disorders (TMDs). However, these studies failed to present a causal relationship. Thus, we aimed to performed a Mendelian randomization (MR) study to investigate causality between BMI and TMDs.

Methods

We performed a two-sample bidirectional MR analysis using large-scale genome-wide association studies (GWAS). Data were obtained from a large-scale BMI dataset (N = 322,154), TMDs dataset (N = 134,280). The causal effects were estimated with inverse-variance weighted (IVW) method, MR Egger, weighted median. Sensitivity analyses were implemented with Cochran's Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis and the funnel plot.<

SUBMITTER: Chen X 

PROVIDER: S-EPMC10355070 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature