Characterization of glucose metabolism in youth with vs. without cystic fibrosis liver disease: A pilot study.

ABSTRACT:

Background

Diabetes and liver disease are life-threatening complications of cystic fibrosis (CF). CF-liver disease is a risk factor for CF related diabetes (CFRD) development, but the underlying mechanisms linking the two co-morbidities are not known. The objective of this pilot study was to characterize glucose metabolism in youth with CF with and without liver disease.

Methods

In this two-center cross-sectional study, 20 youth with CF with and without liver disease underwent a 3-hour oral glucose tolerance test. Subjects were categorized by liver disease (LD) status [no LD, mild LD, severe LD] and diabetes status. Measures of glucose excursion, islet cell secretory responses, insulin sensitivity and clearance were obtained.

Results

Participants with severe LD had th

SUBMITTER: Socorro Rayas M 

PROVIDER: S-EPMC8942823 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature