Risk factors and implications associated with renal mineralization in chronic kidney disease in cats.

ABSTRACT:

Background

Nephrocalcinosis is a pathological feature of chronic kidney disease (CKD). Its pathophysiological implications for cats with CKD are unexplored.

Objectives

Identify nephrocalcinosis risk factors and evaluate its influence on CKD progression and all-cause mortality.

Animals

Fifty-one euthyroid client-owned cats with International Renal Interest Society (IRIS) stages 2-3 azotemic CKD.

Methods

Retrospective cohort study. Histopathological kidney sections were assessed for nephrocalcinosis (von Kossa stain). Nephrocalcinosis severity was determined by image analysis (ImageJ). Ordinal logistic regressions were performed to identify nephrocalcinosis risk factors. The influence of nephrocalcinosis on CKD progression and mortality risk were assessed using l

SUBMITTER: Tang PK 

PROVIDER: S-EPMC8965253 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature