Pregnancy loss and risk of multiple sclerosis and autoimmune neurological disorder: A nationwide cohort study.

ABSTRACT:

Background

The loss of one or more pregnancies before viability (i.e. pregnancy loss or miscarriage), has been linked to an increased risk of diseases later in life such as myocardial infarction and stroke. Recurrent pregnancy loss (i.e. three consecutive pregnancy losses) and multiple sclerosis have both been linked to immunological traits, which could predispose to both occurrences. The objective of the current study was to investigate if pregnancy loss is associated with later autoimmune neurological disease.

Methods

This register-based cohort study, included the Danish female population age 12 or older between 1977-2017. Women were grouped hierarchically: 0, 1, 2, ≥3 pregnancy losses, primary recurrent pregnancy loss (i.e. not preceded by a delivery), and secondary recur

SUBMITTER: Mikkelsen AP 

PROVIDER: S-EPMC8970484 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature