Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy.

ABSTRACT: Tumor immune escape has emerged as the most significant barrier to cancer therapy. A thorough understanding of tumor immune escape therapy mechanisms is critical for further improving clinical treatment strategies. Currently, research indicates that combining several immunotherapies can boost antitumor efficacy and encourage T cells to play a more active part in the immune assault. To generate a more substantial therapeutic impact, it can establish an ideal tumor microenvironment (TME), encourage T cells to play a role, prevent T cell immune function reversal, and minimize tumor immune tolerance. In this review, we will examine the mechanisms of tumor immune escape and the limits of tumor immune escape therapy, focusing on the current development of immunotherapy based on tumor immune esca

SUBMITTER: Aktar N 

PROVIDER: S-EPMC8989557 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature