Circulating Vitamin D Levels and the Risk of Atrial Fibrillation: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Aim

We performed a two-sample Mendelian randomization (MR) analysis to evaluate the association between serum vitamin D levels and atrial fibrillation (AF) risks.

Methods

Data on the single-nucleotide polymorphisms (SNPs) related to vitamin D, 25-hydroxyvitamin D, and AF outcome were obtained from a UK Biobank study, SUNLIGHT consortium, and the latest meta-analysis of genome-wide association studies GWASs with six independent cohorts, respectively. MR analysis was performed to obtain the estimates, followed by the use of inverse variance weighted (IVW) method, weighted median method, maximum likelihood, MR-egger method, and MR-PRESSO methods.

Results

The IVW estimate showed that genetically predicted vitamin D and 25-hydroxyvitamin D levels were not causally associat

SUBMITTER: Yang S 

PROVIDER: S-EPMC8996811 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature