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Neoantigen-specific CD4⁺ T cells in human melanoma have diverse differentiation states and correlate with CD8⁺ T cell, macrophage, and B cell function.

ABSTRACT: CD4⁺ T cells that recognize tumor antigens are required for immune checkpoint inhibitor efficacy in murine models, but their contributions in human cancer are unclear. We used single-cell RNA sequencing and T cell receptor sequences to identify signatures and functional correlates of tumor-specific CD4⁺ T cells infiltrating human melanoma. Conventional CD4⁺ T cells that recognize tumor neoantigens express CXCL13 and are subdivided into clusters expressing memory and T follicular helper markers, and those expressing cytolytic markers, inhibitory receptors, and IFN-γ. The frequency of CXCL13⁺ CD4⁺ T cells in the tumor correlated with the transcriptional states of CD8⁺ T cells and macrophages, maturation of B cells, and patient

SUBMITTER: Veatch JR

PROVIDER: S-EPMC9011147 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Neoantigen-specific CD4⁺ T cells in human melanoma have diverse differentiation states and correlate with CD8⁺ T cell, macrophage, and B cell function.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Neoantigen-specific CD4⁺ T cells in human melanoma have diverse differentiation states and correlate with CD8⁺ T cell, macrophage, and B cell function.