Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.
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ABSTRACT:
SUBMITTER: Du T
PROVIDER: S-EPMC9014743 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
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Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.
Du Ting T Mestre Humberto H Kress Benjamin T BT Liu Guojun G Sweeney Amanda M AM Samson Andrew J AJ Rasmussen Martin Kaag MK Mortensen Kristian Nygaard KN Bork Peter A R PAR Peng Weiguo W Olveda Genaro E GE Bashford Logan L Toro Edna R ER Tithof Jeffrey J Kelley Douglas H DH Thomas John H JH Hjorth Poul G PG Martens Erik A EA Mehta Rupal I RI Hirase Hajime H Mori Yuki Y Nedergaard Maiken M
Brain : a journal of neurology 20220401 2
Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that oedema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of CSF. Oedema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of oedema. Oedema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex ...[more]
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