Synchrotron XRF Analysis Identifies Cerium Accumulation Colocalized with Pharyngeal Deformities in CeO₂ NP-Exposed Caenorhabditis elegans.

ABSTRACT: A combination of synchrotron radiation-based elemental imaging, in vivo redox status analysis, histology, and toxic responses was used to investigate the uptake, biodistribution, and adverse effects of Ce nanoparticles (CeO₂ NP; 10 nm; 0.5-34.96 mg Ce L^-1) or Ce(NO₃)₃ (2.3-26 mg Ce L^-1) in Caenorhabditis elegans. Elemental mapping of the exposed nematodes revealed Ce uptake in the alimentary canal prior to depuration. Retention of CeO₂ NPs was low compared to that of Ce(NO₃)₃ in depurated individuals. X-ray fluorescence (XRF) mapping showed that Ce translocation was confined to the pharyngeal valve and foregut. Ce(NO₃)₃ exposure significantly decreased growth, fertility, and

SUBMITTER: Rossbach LM 

PROVIDER: S-EPMC9022427 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature