Quantitative 3D Ultrashort Echo Time Magnetization Transfer Imaging for Evaluation of Knee Cartilage Degeneration In Vivo.

ABSTRACT:

Background

Recent studies suggest that macromolecular fraction (MMF) derived from three-dimensional ultrashort echo time magnetization transfer (UTE-MT) imaging is insensitive to the magic angle effect. However, its clinical use in osteoarthritis (OA) remains to be investigated.

Purpose

To investigate the feasibility of 3D UTE-MT-derived MMF in differentiating normal from degenerated cartilage.

Study type

Prospective.

Subjects

Sixty-two participants (54.8 ± 16.7 years, 30 females) with and without OA, plus two healthy volunteers (mean age 35.0 years) for reproducibility test.

Field strength/sequence

3 T/UTE-MT sequence.

Assessment

A 3D UTE-MT sequence was employed to calculate MMF based on a two-pool model. Kellgren-Lawrence (KL) grade and Whole-O

SUBMITTER: Xue YP 

PROVIDER: S-EPMC9022479 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature