A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling.

ABSTRACT: Conventional synthetic vascular grafts are associated with significant failure rates due to their mismatched mechanical properties with the native vessel and poor regenerative potential. Though different tissue engineering approaches have been used to improve the biocompatibility of synthetic vascular grafts, it is still crucial to develop a new generation of synthetic grafts that can match the dynamics of native vessel and direct the host response to achieve robust vascular regeneration. The size of pores within implanted biomaterials has shown significant effects on macrophage polarization, which has been further confirmed as necessary for efficient vascular formation and remodeling. Here, we developed biodegradable, autoclavable synthetic vascular grafts from a new polyurethane elastome

SUBMITTER: Stahl A 

PROVIDER: S-EPMC9034314 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature