Modeling the evolution of SARS-CoV-2 under non-pharmaceutical interventions and testing.

ABSTRACT:

Background and objectives

Social and behavioral non-pharmaceutical interventions (NPIs), such as mask-wearing, social distancing and travel restrictions, as well as diagnostic tests, have been broadly implemented in response to the COVID-19 pandemic. Epidemiological models and data analysis affirm that wide adoption of NPIs helps to control the pandemic. However, SARS-CoV-2 has extensively demonstrated its ability to evolve. Therefore, it is crucial to examine how NPIs may affect the evolution of the virus. Such evolution could have important effects on the spread and impact of the pandemic.

Methodology

We used evo-epidemiological models to examine the effect of NPIs and testing on two evolutionary trajectories for SARS-CoV-2: attenuation and test evasion.

Results

Our

SUBMITTER: Gurevich Y 

PROVIDER: S-EPMC9046092 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature