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Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones.

ABSTRACT: We report a cesium bicarbonate-mediated alkylation of 2,4-dihydroxybenzyaldehyde and 2,4-dihydroxyacetophenone to generate 4-alkylated products in acetonitrile at 80 °C with excellent regioselectivity, up to 95% isolated yields, and broad substrate scope.

SUBMITTER: Frank A

PROVIDER: S-EPMC9053733 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones.

Frank Aziza A Hamidi Negar N Hamidi Negar N Xue Fengtian F

Tetrahedron letters 20220323

We report a cesium bicarbonate-mediated alkylation of 2,4-dihydroxybenzyaldehyde and 2,4-dihydroxyacetophenone to generate 4-alkylated products in acetonitrile at 80 °C with excellent regioselectivity, up to 95% isolated yields, and broad substrate scope. ...[more]

PMID: 35495552

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