Effects of white matter hyperintensities, neuropsychiatric symptoms, and cognition on activities of daily living: Differences between Alzheimer's disease and dementia with Lewy bodies.
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ABSTRACT: Introduction
Disability is common across Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). White matter hyperintensities (WMHs) are prevalent in both diagnoses and associated with disability; both diagnoses show neuropsychiatric symptoms (NPS) and impaired cognition.Methods
In AD and DLB, we examined if WMHs, NPS, and cognition associate with basic and/or instrumental activities of daily living (BADLs and/or IADLs) cross-sectionally, and longitudinally over ≈1.4 years.Results
Across both diagnoses, NPS were not only associated with greater disability in performing both BADLs and IADLs, but were also associated with a decline in the ability to perform BADLs in the AD group. In the DLB group only, higher WMH volume was associated with greater disability in performing both BADLs and IADLs, and was associated with a decline in the ability to perform BADL over time.Discussion
Management of NPS and WMHs, particularly in DLB, might help maintain functionality in dementia patients for longer.
SUBMITTER: Mirza SS
PROVIDER: S-EPMC9060552 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Effects of white matter hyperintensities, neuropsychiatric symptoms, and cognition on activities of daily living: Differences between Alzheimer's disease and dementia with Lewy bodies.
Mirza Saira Saeed SS Saeed Usman U Ramirez Joel J Herrmann Nathan N Stuss Donald T DT Black Sandra E SE Masellis Mario M
Alzheimer's & dementia (Amsterdam, Netherlands) 20220502 1
<h4>Introduction</h4>Disability is common across Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). White matter hyperintensities (WMHs) are prevalent in both diagnoses and associated with disability; both diagnoses show neuropsychiatric symptoms (NPS) and impaired cognition.<h4>Methods</h4>In AD and DLB, we examined if WMHs, NPS, and cognition associate with basic and/or instrumental activities of daily living (BADLs and/or IADLs) cross-sectionally, and longitudinally over ≈1.4 years ...[more]
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