Urinary phthalate metabolite mixtures in pregnancy and fetal growth: Findings from the infant development and the environment study.

ABSTRACT:

Background

Prenatal phthalate exposure has been linked to reductions in fetal growth in animal and laboratory studies, but epidemiologic evidence is equivocal.

Objective

Examine the association between prenatal phthalate metabolite mixtures and fetal growth and evaluate whether that association is modified by fetal sex or omega-3 intake during pregnancy.

Methods

Analyses included 604 singleton pregnancies from TIDES, a prospective pregnancy cohort with spot urine samples and questionnaires collected in each trimester. Pregnancy-averaged phthalate exposure estimates were calculated as the geometric means of specific-gravity corrected phthalate metabolites. Fetal growth outcomes included birthweight and length, and ultrasound-derived size and velocity of estimated fetal

SUBMITTER: Stevens DR 

PROVIDER: S-EPMC9075822 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature