Ontology highlight
ABSTRACT:
SUBMITTER: Rahman SA
PROVIDER: S-EPMC9089783 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Rahman Sheikh Abdul SA Billingsley James M JM Sharma Ashish Arunkumar AA Styles Tiffany M TM Govindaraj Sakthivel S Shanmugasundaram Uma U Babu Hemalatha H Riberio Susan Pereira SP Ali Syed A SA Tharp Gregory K GK Ibegbu Chris C Waggoner Stephen N SN Johnson R Paul RP Sekaly Rafick-Pierre RP Villinger Francois F Bosinger Steve E SE Amara Rama Rao RR Velu Vijayakumar V
JCI insight 20220422 8
The persistence of virally infected cells as reservoirs despite effective antiretroviral therapy is a major barrier to an HIV/SIV cure. These reservoirs are predominately contained within cells present in the B cell follicles (BCFs) of secondary lymphoid tissues, a site that is characteristically difficult for most cytolytic antiviral effector cells to penetrate. Here, we identified a population of NK cells in macaque lymph nodes that expressed BCF-homing receptor CXCR5 and accumulated within BC ...[more]