CTLA4⁺CD4⁺CXCR5^-FOXP3⁺ T cells associate with unfavorable outcome in patients with chronic HBV infection.

ABSTRACT:

Background

A major barrier to achieving a favorable outcome of chronic HBV infection is a dysregulated HBV-specific immune response resulting from immunosuppressive features of FOXP3⁺ T cells. A better definition of FOXP3⁺ T cells is essential for improving the prognosis of HBV infection. We aimed to investigate the role of CD4⁺CXCR5^-FOXP3⁺ T cells with CTLA4 expression in patients with chronic HBV infection.

Methods

Treatment-naïve chronic HBV-infected patients, HBV-related hepatic failure, and a longitudinal cohort of chronic hepatitis B (CHB) patients with nucleos(t)ide analogue treatment were enrolled for analysis of CD4⁺CXCR5^-FOXP3⁺ T cell responses by flow cytometry and single-cell

SUBMITTER: Wen C 

PROVIDER: S-EPMC9835316 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature