An Ultrasound-Guided Hemispherical Phased Array for Microbubble-Mediated Ultrasound Therapy.

ABSTRACT:

Goal

To develop a low-cost magnetic resonance imaging (MRI)-free transcranial focused ultrasound (FUS) system for microbubble-mediated therapy.

Methods

A 128-element 11 MHz array for skull localization was integrated within a 256-module multi-frequency (306/612/1224 kHz) dual-mode phased array. The system's transcranial transmit and receive performance was evaluated with ex-vivo human skullcaps using phase aberration corrections calculated from computed tomography (CT)-based simulations via ultrasound-based (USCT) and landmark-based (LMCT) registrations, and a gold-standard fixed source emitter (FSE)-based method.

Results

Displacement and rotation registration errors of 1.4 ± 0.4 mm and 2.1 ± 0.2 ^° were obtained using USCT, resulting in sub-millimeter trans

SUBMITTER: Deng L 

PROVIDER: S-EPMC9092225 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature