Effect of Initial Anticoagulation Targets on Bleeding and Thrombotic Complications for Patients With Acute Respiratory Distress Syndrome Receiving Extracorporeal Membrane Oxygenation.

ABSTRACT:

Objective

To evaluate the effect of anticoagulation targets and intensity on bleeding events, thrombotic events, and transfusion requirements in patients with acute respiratory distress syndrome (ARDS) receiving venovenous extracorporeal membrane oxygenation (ECMO) and continuous-infusion heparin.

Design

A retrospective cohort study.

Setting

At a single-center, large academic medical center.

Participants

One hundred thirty-six critically ill patients.

Interventions

The following three therapeutic targets were implemented over time and evaluated: (1) no protocol (September 2013-August 2016): no standardized anticoagulation protocol or transfusion thresholds; (2) <50 seconds (September 2016-January 2018): standardized activated partial thromboplastin time

SUBMITTER: Cercone JL 

PROVIDER: S-EPMC9101777 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature