Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.
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ABSTRACT:
SUBMITTER: Gelegen C
PROVIDER: S-EPMC9105586 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.
Gelegen Cigdem C Cash Diana D Ilic Katarina K Sander Millie M Kim Eugene E Simmons Camilla C Bernanos Michel M Lama Joana J Randall Karen K Brown Jonathan T JT Kalanj-Bognar Svjetlana S Cooke Samuel S Ray Chaudhuri K K Ballard Clive C Francis Paul P Rosenzweig Ivana I
Scientific reports 20220513 1
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread slee ...[more]
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