Dataset Information

Retrograde Procedural Memory in Parkinson's Disease: A Cross-Sectional, Case-Control Study.

ABSTRACT:

Background

The analysis of the procedural memory is particularly relevant in neurodegenerative disorders like Parkinson's disease, due to the central role of the basal ganglia in procedural memory. It has been shown that anterograde procedural memory, the ability to learn a new skill, is impaired in Parkinson's disease. However, retrograde procedural memory, the long-term retention and execution of skills learned in earlier life stages, has not yet been systematically investigated in Parkinson's disease.

Objective

This study aims to investigate retrograde procedural memory in people with Parkinson's disease. We hypothesized that retrograde procedural memory is impaired in people with Parkinson's disease compared to an age- and gender-matched control group.

Methods

First, we developed the CUPRO evaluation system, an extended evaluation system based on the Cube Copying Test, to distinguish the cube copying procedure, representing functioning of retrograde procedural memory, and the final result, representing the visuo-constructive abilities. Development of the evaluation system included tests of discriminant validity.

Results

Comparing people with typical Parkinson's disease (n = 201) with age- and gender-matched control subjects (n = 201), we identified cube copying performance to be significantly impaired in people with Parkinson's disease (p = 0.008). No significant correlation was observed between retrograde procedural memory and disease duration.

Conclusion

We demonstrated lower cube copying performance in people with Parkinson's disease compared to control subjects, which suggests an impaired functioning of retrograde procedural memory in Parkinson's disease.

SUBMITTER: Pauly L

PROVIDER: S-EPMC9108589 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Retrograde Procedural Memory in Parkinson's Disease: A Cross-Sectional, Case-Control Study.

Pauly Laure L Pauly Claire C Hansen Maxime M Schröder Valerie E VE Rauschenberger Armin A Leist Anja K AK Krüger Rejko R

Journal of Parkinson's disease 20220101 3

<h4>Background</h4>The analysis of the procedural memory is particularly relevant in neurodegenerative disorders like Parkinson's disease, due to the central role of the basal ganglia in procedural memory. It has been shown that anterograde procedural memory, the ability to learn a new skill, is impaired in Parkinson's disease. However, retrograde procedural memory, the long-term retention and execution of skills learned in earlier life stages, has not yet been systematically investigated in Par ...[more]

PMID: 35147550

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Dataset Information

Retrograde Procedural Memory in Parkinson's Disease: A Cross-Sectional, Case-Control Study.

Background

Objective

Methods

Results

Conclusion

Publications

Retrograde Procedural Memory in Parkinson's Disease: A Cross-Sectional, Case-Control Study.

Similar Datasets

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