Sex differences in M2 polarization, chemokine and IL-4 receptors in monocytes and macrophages from asthmatics.

ABSTRACT: Allergic asthma affects more women than men. It is mediated partially by IL-4/IL-13-driven polarization of monocyte-derived macrophages in the lung. We tested whether sex differences in asthma are due to differential IL-4 responsiveness and/or chemokine receptor expression in monocytes and monocyte-derived macrophages from healthy and allergic asthmatic men and women. We found female cells expressed M2 genes more robustly following IL-4 stimulation than male cells, as did cells from asthmatics than those from healthy controls. This likely resulted from increased expression ofγC, part of the type I IL-4 receptor, and reduced IL-4-induced SOCS1, a negative regulator of IL-4 signaling, in asthmatic compared to healthy macrophages. Monocytes from asthmatic women expressed more CX3CR1, which en

SUBMITTER: Becerra-Diaz M 

PROVIDER: S-EPMC9109226 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature