Associations of Parity With Change in Global Cognition and Incident Cognitive Impairment in Older Women.

ABSTRACT:

Background

The evidence of the association between parity and risk of mild cognitive impairment (MCI) or dementia is mixed, and the relationship between parity and longitudinal cognitive changes is less clear. We investigated these issues in a large population of older women who were carefully monitored for development of MCI and probable dementia.

Methods

Using the Women's Health Initiative Memory Study, 7,100 postmenopausal women (mean age 70.1 ± 3.8 years) with information on baseline parity (defined as the number of term pregnancies), measures of global cognition (Modified Mini-Mental State Examination score) from 1996-2007, and cognitive impairment (centrally adjudicated diagnoses of MCI and dementia) from 1996-2016 were included. Multivariable linear mixed-effects mode

SUBMITTER: Zhou R 

PROVIDER: S-EPMC9114765 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature