Identifying the Common Genetic Basis of Antidepressant Response.

ABSTRACT:

Background

Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success of previous genome-wide association studies has been limited by sample size. This study performs the largest genetic analysis of prospectively assessed antidepressant response in major depressive disorder to gain insight into the underlying biology and enable out-of-sample prediction.

Methods

Genome-wide analysis of remission (n _remit = 1852, n _nonremit = 3299) and percentage improvement (n = 5218) was performed. Single nucleotide polymorphism-based heritability was estimated using genome-

SUBMITTER: Pain O 

PROVIDER: S-EPMC9117153 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature