Association of Obesity and Luminal Subtypes in Prognosis and Adjuvant Endocrine Treatment Effectiveness Prediction in Chinese Breast Cancer Patients.

ABSTRACT:

Purpose

To evaluate the influence of obesity on clinicopathological characteristics of breast cancer; to explore the effect of obesity on the prognosis and performance of endocrine therapy in breast cancer patients.

Methods

Patients with luminal/HER2-negative early breast cancer were included and categorized into the non-obese (BMI<28kg/m²) and obese (BMI≥28kg/m²) groups according to body mass index (BMI). Clinicopathological characteristics and treatment modalities were compared between groups. Interaction of adjuvant endocrine therapy with obesity was analyzed.

Results

A total of 2,875 patients were included: 2,598 non-obese and 277 obese. A higher rate of patients with comorbidities (OR: 2.83, 95%CI 2.13-3.74, P<0.001) or PR-positive tu

SUBMITTER: Tong Y 

PROVIDER: S-EPMC9117630 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature