Epigenetic quantification of immunosenescent CD8⁺ TEMRA cells in human blood.

ABSTRACT: Age-related changes in human T-cell populations are important contributors to immunosenescence. In particular, terminally differentiated CD8⁺ effector memory CD45RA⁺ TEMRA cells and their subsets have characteristics of cellular senescence, accumulate in older individuals, and are increased in age-related chronic inflammatory diseases. In a detailed T-cell profiling among individuals over 65 years of age, we found a high interindividual variation among CD8⁺ TEMRA populations. CD8⁺ TEMRA proportions correlated positively with cytomegalovirus (CMV) antibody levels, however, not with the chronological age. In the analysis of over 90 inflammation proteins, we identified plasma TRANCE/RANKL levels to associate with several differentiated T-cell popula

SUBMITTER: Salumets A 

PROVIDER: S-EPMC9124311 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature