Clinical Features and Natural History of Preadolescent Nonsyndromic Hypertrophic Cardiomyopathy.

ABSTRACT:

Background

Up to one-half of childhood sarcomeric hypertrophic cardiomyopathy (HCM) presents before the age of 12 years, but this patient group has not been systematically characterized.

Objectives

The aim of this study was to describe the clinical presentation and natural history of patients presenting with nonsyndromic HCM before the age of 12 years.

Methods

Data from the International Paediatric Hypertrophic Cardiomyopathy Consortium on 639 children diagnosed with HCM younger than 12 years were collected and compared with those from 568 children diagnosed between 12 and 16 years.

Results

At baseline, 339 patients (53.6%) had family histories of HCM, 132 (20.9%) had heart failure symptoms, and 250 (39.2%) were prescribed cardiac medications. The median maxima

SUBMITTER: Norrish G 

PROVIDER: S-EPMC9125690 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature