DisPhaseDB: An integrative database of diseases related variations in liquid-liquid phase separation proteins.

ABSTRACT:

Motivation

Proteins involved in liquid-liquid phase separation (LLPS) and membraneless organelles (MLOs) are recognized to be decisive for many biological processes and also responsible for several diseases. The recent explosion of research in the area still lacks tools for the analysis and data integration among different repositories. Currently, there is not a comprehensive and dedicated database that collects all disease-related variations in combination with the protein location, biological role in the MLO, and all the metadata available for each protein and disease. Disease-related protein variants and additional features are dispersed and the user has to navigate many databases, with a different focus, formats, and often not user friendly.

Results

We present DisPhaseDB

SUBMITTER: Navarro AM 

PROVIDER: S-EPMC9156858 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature