PPARɣ2, aldose reductase, and TCF7L2 gene polymorphisms: relation to diabetes mellitus.

ABSTRACT:

Purpose

Diabetes mellitus (DM) is a growing global health concern. Genetic factors play a pivotal role in the development of diabetes. Therefore, the present work aimed to study the relation between peroxisome proliferator-activate receptors (PPARɣ2) (rs3856806), aldose reductase (AR) (rs759853), transcription factor 7 like 2 (TCF7L2) (rs7903146) gene polymorphism with diabetes in the Egyptian population.

Methods

The study included 260 diabetics and 120 healthy subjects. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism.

Results

Regression analysis revealed that PPARɣ2 TT, TCF7L2 TT were suggested to be independent risk predictors for T1DM and TCF7L2 TC, CC genotype were suggested to be independent protective factors against

SUBMITTER: Shawki HA 

PROVIDER: S-EPMC9167404 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature