Prevention-effective adherence trajectories among transgender women indicated for PrEP in the United States: a prospective cohort study.

ABSTRACT:

Purpose

Adherence to pre-exposure prophylaxis (PrEP) during periods of PrEP-indication (i.e., prevention-effective adherence) is critical for preventing HIV. We sought to describe factors associated with prevention-effective adherence trajectories among transgender women (TW) to inform PrEP implementation strategies.

Methods

Using data from The LITE American Cohort (n = 728), we performed group-based multi-trajectory modeling (GBMTM) to identify clusters of TW with similar trajectories of PrEP adherence and indication, and sociodemographic, biobehavioral, and structural correlates of each trajectory.

Results

We identified five trajectories: (1) consistent indication/no PrEP (15.3%), (2) initial indication/no PrEP (47.1%), (3) declining indication/discontinued PrEP (9.

SUBMITTER: Cooney EE 

PROVIDER: S-EPMC9167788 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature