A novel non-invasive method allowing for discovery of pathologically relevant proteins from small airways.

ABSTRACT:

Background

There is a lack of early and precise biomarkers for personalized respiratory medicine. Breath contains an aerosol of droplet particles, which are formed from the epithelial lining fluid when the small airways close and re-open during inhalation succeeding a full expiration. These particles can be collected by impaction using the PExA^® method (Particles in Exhaled Air), and are derived from an area of high clinical interest previously difficult to access, making them a potential source of biomarkers reflecting pathological processes in the small airways.

Research question

Our aim was to investigate if PExA method is useful for discovery of biomarkers that reflect pathology of small airways.

Methods and analysis

Ten healthy controls and 20 subjects

SUBMITTER: Ostling J 

PROVIDER: S-EPMC9167914 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature