Gut microbiota development during infancy: Impact of introducing allergenic foods.

ABSTRACT:

Background

The gut microbiota potentially plays an important role in the immunologic education of the host during early infancy.

Objective

We sought to determine how the infant gut microbiota evolve during infancy, particularly in relation to hygiene-related environmental factors, atopic disorders, and a randomized introduction of allergenic solids.

Methods

A total of 1303 exclusively breast-fed infants were enrolled in a dietary randomized controlled trial (Enquiring About Tolerance study) from 3 months of age. In this nested longitudinal study, fecal samples were collected at baseline, with additional sampling of selected cases and controls at 6 and 12 months to study the evolution of their gut microbiota, using 16S ribosomal RNA gene-targeted amplicon sequencing.

SUBMITTER: Marrs T 

PROVIDER: S-EPMC9169695 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature