Two-Year Responses of Renal Function to First Occupational Lead Exposure.

ABSTRACT:

Introduction

Whether in advanced countries lead exposure still contributes to renal impairment is debated, because blood lead (BL) level is declining toward preindustrial levels and because longitudinal studies correlating renal function and BL changes over time are scarce.

Methods

The Study for Promotion of Health in Recycling Lead (SPHERL) evaluated the 2-year renal function responses in 251 workers (mean age, 29.7 years) transiting from environmental to occupational exposure. Main study end point was the estimated glomerular filtration rate (eGFR) derived from serum creatinine (eGFRcrt), cystatin C (eGFRcys), or both (eGFRcc). BL level was measured by inductively coupled plasma mass spectrometry (detection limit 0.5 μg/dl).

Results

In the follow-up, mean baseline B

SUBMITTER: Yu YL 

PROVIDER: S-EPMC9171623 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature