Maternal prepregnancy weight and gestational weight gain in association with autism and developmental disorders in offspring.

ABSTRACT:

Objective

Maternal prepregnancy BMI and gestational weight gain (GWG) are examined in relation to autism spectrum disorder (ASD) and other developmental disorders (DD) in offspring in a multisite case-control study.

Methods

Maternal prepregnancy BMI, obtained from medical records or self-report, was categorized as underweight, normal weight, overweight, obesity Class 1, or obesity Class 2/3. GWG was standardized for gestational age (GWG z score), and the rate (pounds/week) was categorized per adherence with clinical recommendations. Logistic regression models, adjusting for demographic factors, were used to assess associations with ASD (n = 1,159) and DD (n = 1,617), versus control children (n = 1,633).

Results

Maternal obesity Class 2/3 was associated with ASD (adjus

SUBMITTER: Matias SL 

PROVIDER: S-EPMC9186321 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature