Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity.

ABSTRACT:

Purpose

Although insomnia and migraine are often comorbid, the genetic association between insomnia and migraine remains unclear. This study aimed to identify susceptibility loci associated with insomnia and migraine comorbidity.

Patients and methods

We performed a genome-wide association study (GWAS) involving 1063 clinical outpatients at a tertiary hospital in Taiwan. Migraineurs with and without insomnia were genotyped using the Affymetrix Axiom Genome-Wide TWB 2.0. We performed association analyses for the entire cohort and stratified patients into the following subgroups: episodic migraine (EM), chronic migraine (CM), migraine with aura (MA), and migraine without aura (MoA). Potential correlations between SNPs and clinical indices in migraine patients with insomnia were

SUBMITTER: An YC 

PROVIDER: S-EPMC9188338 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature