Identification of Liver and Plasma microRNAs in Chronic Hepatitis B Virus infection.

ABSTRACT:

Background and aims

With current standard of care a functional cure for Chronic Hepatitis B (CHB) is only achieved in 1-3% of patients and therefore novel therapies are needed. Disease activity during CHB can be determined by a broad range of virological biomarkers, however these biomarkers are also targets for novel treatment strategies. The aim of this study was to identify novel miRNAs that are differentially expressed in plasma and liver in CHB, and determine whether these miRNAs may serve as biomarkers of disease stage or treatment outcome.

Methods

miRNA Next-Generation-Sequencing of plasma and liver samples from CHB patient and controls was performed to identify differentially expressed miRNAs. The identified candidate miRNAs were validated by qPCR in additional plasma

SUBMITTER: Loukachov VV 

PROVIDER: S-EPMC9201251 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature