LncRNA PAINT is associated with aggressive prostate cancer and dysregulation of cancer hallmark genes.
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ABSTRACT:
SUBMITTER: Hasan MF
PROVIDER: S-EPMC9211384 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
LncRNA PAINT is associated with aggressive prostate cancer and dysregulation of cancer hallmark genes.
Hasan Md Faqrul MF Ganapathy Kavya K Sun Jiao J Khatib Ayman A Andl Thomas T Soulakova Julia N JN Coppola Domenico D Zhang Wei W Chakrabarti Ratna R
International journal of cancer 20210317
Long noncoding RNAs (lncRNAs) play regulatory role in cellular processes and their aberrant expression may drive cancer progression. Here we report the function of a lncRNA PAINT (prostate cancer associated intergenic noncoding transcript) in promoting prostate cancer (PCa) progression. Upregulation of PAINT was noted in advanced stage and metastatic PCa. Inhibition of PAINT decreased cell proliferation, S-phase progression, increased expression of apoptotic markers, and improved sensitivity to ...[more]
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